Trevi Therapeutics, Inc.
The research page contains a warning that has not been mapped to a supported model interpretation. The company research remains available, but the complete score is withheld until the warning is reviewed.
TRVI · Price history
Price at last available close
$13.52
−$0.90 (-6.24%) 1M
2026-10-28
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Company & revenue
About Trevi Therapeutics, Inc.
Primary reporting period: 2025-12-31 · Research updated Oct 12, 2026. A research update is not a new financial filing.
Who they are
Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the advancement and commercialization of Haduvio, a potential treatment for debilitating neurologically mediated conditions. This orally administered, extended-release formulation of nalbuphine is currently undergoing Phase IIb/III clinical trials for chronic pruritus (severe itching) and persistent cough experienced by patients with idiopathic pulmonary fibrosis. Trevi Therapeutics also possesses a licensing agreement with Endo Pharmaceuticals Inc., granting it the rights to develop and market products containing nalbuphine hydrochloride in various formulations.
How they make money
Trevi Therapeutics is a clinical-stage biopharmaceutical company that does not currently generate revenue from product sales. Its business model focuses on the research and development of its investigational therapy, Haduvio, with the goal of obtaining regulatory approval and eventually commercializing the product to treat chronic pruritus and chronic cough.
Products & services
Haduvio (oral nalbuphine ER), an investigational oral extended-release formulation of nalbuphine, a small molecule opioid mixed agonist-antagonist.
Brands & revenue mix
Investigational oral extended-release formulation of nalbuphine.
Separate brand revenue is not available in this research.Source
Revenue share is not unit sales or a best-seller ranking. Parent brands and included sub-brands can overlap; do not add overlapping rows.
Product / operating segments
No reconciled product or operating-segment revenue breakdown is available for the current research period. Company-wide revenue remains separate from segment disclosure.
Geographic revenue
No reconciled geographic revenue breakdown was confirmed for the current research period.
Customer concentration
No quantified customer-concentration disclosure is available in the current saved research.
Suppliers, materials & equipment
- Contract Manufacturing Organizations — The company relies on third-party contract manufacturing organizations for the production of its clinical trial materials and drug product.Source
Strengths
- Proprietary clinical-stage pipeline focused on HaduvioSource
Sources
Company-specific research
Questions worth answering for TRVI
These questions are generated from this company's current financial and score data so the page adds context instead of treating the headline score as a stand-alone conclusion.
- •How long can TRVI fund negative free cash flow using its current cash position before it may need more debt or new shares?
- •How is TRVI likely to use its cash advantage: reinvestment, acquisitions, debt reduction, dividends or buybacks?
- •What specifically needs to improve for TRVI to reach sustainable profitability?
- •What future growth or profitability would be needed to justify TRVI's current valuation?
- •What does the current fundamental change risk warning mean for the reliability or interpretation of TRVI's score?
Essential Investment Snapshot
Market Cap
$1.93B
P/E Ratio
-42.9
EPS
$-0.34
52-Week High
$20.22
52-Week Low
$9.28
Beta
1.05
Analyst Target
$27.50
Shares Outstanding
145.1M
Total Debt
$605K
Dividend
No current dividend
Liquidation Value / Share
$2.22
Momentum & Volatility Signals
Two different market-behavior signals. Momentum measures direction and trend strength. Volatility measures how large and unstable the price moves are, regardless of direction.
Weakening momentum
Normal movement
A high momentum score means price has been trending upward with confirming short- and medium-term strength. A low score means downward or weakening momentum.
A high volatility score means larger, less stable price swings. It can happen while a stock is rising or falling, so high volatility is not automatically bullish or bearish.
Important: the volatility score above is based on realized price volatility. Implied volatility (IV) comes from options prices and represents the market's expected future movement. Wall Street Score will keep IV separate and will only display it when a verified options-chain feed is available.
Community Sentiment
0 active · 0 total callsNo personal call yet on TRVI.
Potential upside factors
- +Growth opportunities may come from revenue expansion, margin improvement, new products, market-share gains, and stronger cash flow.
- +Proprietary clinical-stage pipeline focused on Haduvio.
Potential downside factors
- −Key risks may include competition, margin pressure, debt levels, valuation risk, and changes in demand within the Biotechnology industry.
- −History of operating losses and expectation of future losses.
- −Dependence on the success of a single product candidate, Haduvio.
- −Significant capital requirements for clinical development and regulatory approval.
These research factors come from saved company research and financial data, not community votes. They are starting points to verify against filings, not buy or sell recommendations.
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Scores
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Score Changes
Score changes will appear once more historical records are available.
Price vs. Value
Valuation unavailableCurrent Price
$13.52
Model Intrinsic Value
—
Difference
—
Margin of Safety
—
Intrinsic value is not currently available for this stock, so valuation can't be calculated.
Financial Charts
Revenue
Additional Metrics
Operating Cash Flow
Total Debt
Total Assets
Net Margin %
Free includes 3 annual periods plus available TTM; Premium includes up to 10 annual periods. History depends on available company filings. Swipe the table horizontally to see older periods. A dash means unavailable, not zero.
| Line Item | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0.00 | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Cost of Revenue | $34K | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Gross Profit | -$34K | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Research & Development | $41.4M | $33.5M | $39.4M | $23.7M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| SG&A Expenses | $18.2M | $15.8M | $12.1M | $10.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Expenses | $59.6M | $49.3M | $51.5M | $33.9M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| EBITDA | -$51.1M | -$42.7M | -$47.8M | -$28.6M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Income | -$59.6M | -$49.3M | -$51.5M | -$33.9M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Interest Expense | $0.00 | $0.00 | $4K | $391K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Before Tax | -$51.2M | -$42.8M | -$47.9M | -$29.1M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Tax Expense | -$70K | -$64K | -$30K | -$32K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Net Income | -$51.1M | -$42.8M | -$47.9M | -$29.1M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic EPS | $-0.34 | $-0.29 | $-0.47 | $-0.29 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic Shares | 157M | 145M | 101M | 99.03M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Diluted Shares | 157M | 145M | 101M | 99.03M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
Earnings Summary
Revenue
$0
Estimate unavailable.
Revenue Beat/Miss
Not available (no estimate stored)
EPS
-$0.11
Estimate unavailable.
EPS Beat/Miss
Not available (no estimate stored)
Debt Change
-32.1%
Cash Change
-53.6%
Margin Change
Not available
Debt and cash show percentage changes versus the comparison period; margin shows the change in percentage points (pp). These are company-wide changes, not per-share amounts.
Financial Changes Since Prior Period
What Improved
- Debt reduced
What Weakened
- Cash position declined
Potential Score Impact
Positive indicators included EPS growth, debt levels. Pressure indicators included cash levels. These factors may support or pressure the Revenue, Management, Financial, and Debt categories; this summary does not claim that the stored scores changed.
Stored Earnings Analysis
EPS increased 16.5%. Cash declined 53.6%. Total debt declined 32.1%.
Earnings-Call Transcript
Earnings-call transcript analysis is not currently available.
These results may influence future scores when the next evaluation is completed.
Insider Activity
Guru / Smart Money
Guru Score
7
Smart Money
7
Number of Gurus
1
Total Guru Value
Avg Portfolio Weight
Largest Holder
Largest Holder %
New Positions
Increased Positions
Reduced Positions
Exited Positions
Net Guru Sentiment
Short Interest
Dividend History
Dividend data is not available yet. Missing data does not mean this company pays no dividend.
Conservative Projected Values
3 Years
$———.——
5 Years
$———.——
10 Years
$———.——
Conservative Projection Rate
——%
Conservative Projected Values — price projections derived from actual 10-year adjusted historical returns, conservatively adjusted and capped at 8% annually. These are distinct from the Outperformance Model Score and WallStreetScore.
Conservative Projected Values
Premium unlocks the 3-year, 5-year, and 10-year conservative projected values with full calculation breakdowns based on actual historical returns.
Start 7-Day Free TrialHistorical Outperformance Record
Premium includes stored forecasts and any available evaluated results. Completed results, win rates and calibrated probabilities are shown only when supported records exist; access does not create historical outcomes.
Start 7-Day Free TrialHistorical Trends
2 historical records2 historical score records available.
Historical Score Chart
2 of 2 records shownWall Street Score
Debt Score
Revenue Score
Asset Score
Capital Score
Management Score
Moat Score
Valuation Score
Buffett Score
Intrinsic Value
Value Reference
Margin of Safety %
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Rumor Mill · TRVI
Corporate developments & opportunities
No reviewed developments match this filter.
Evidence credibility is not a forecast of stock performance. Rumor Mill is separate from the WSS score.
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