Ultragenyx Pharmaceutical Inc.
The research page contains a warning that has not been mapped to a supported model interpretation. The company research remains available, but the complete score is withheld until the warning is reviewed.
RARE · Price history
Price at last available close
$17.20
+$1.88 (+12.27%) 1M
2026-10-28
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Company & revenue
About Ultragenyx Pharmaceutical Inc.
Primary reporting period: 2025-12-31 · Research updated Oct 12, 2026. A research update is not a new financial filing.
Who they are
Ultragenyx Pharmaceutical Inc. is a biopharmaceutical firm dedicated to discovering, developing, and commercializing innovative treatments for rare and ultra-rare genetic conditions. Its operations span North America, Europe, and other international markets. The company's portfolio of marketed biologic products addresses several serious diseases.
How they make money
Ultragenyx is a biopharmaceutical company that generates revenue primarily through the commercialization and sale of novel therapies for rare and ultra-rare genetic diseases. The company utilizes a strategy of identifying, acquiring, and developing therapeutic candidates, which are then sold to healthcare providers, specialty pharmacies, and distributors in the United States and international markets.
Products & services
The company markets and sells therapeutic products including Crysvita (burosumab) for X-linked hypophosphatemia, Dojolvi (triheptanoin) for long-chain fatty acid oxidation disorders, and Evkeeza (evinacumab) for homozygous familial hypercholesterolemia.
Brands & revenue mix
Therapy for X-linked hypophosphatemia.
Separate brand revenue is not available in this research.Source
Therapy for long-chain fatty acid oxidation disorders.
Separate brand revenue is not available in this research.Source
Therapy for homozygous familial hypercholesterolemia.
Separate brand revenue is not available in this research.Source
Revenue share is not unit sales or a best-seller ranking. Parent brands and included sub-brands can overlap; do not add overlapping rows.
Product / operating segments
Geographic revenue
Period ended 2025-12-31Source
Period ended 2025-12-31Source
Period ended 2025-12-31Source
Period ended 2025-12-31Source
Calculated from reported segment revenue. Check the source period and revenue basis before comparing shares. Categories can overlap and may not add to 100%.
Customer concentration
The company discloses that a significant portion of its revenue is derived from a limited number of specialty pharmacy providers and distributors, which is typical for rare disease therapeutics.
Suppliers, materials & equipment
- Catalent — Contract manufacturing and development services provider.Source
Business relationships & partnerships
- Kyowa Kirin — A strategic collaboration for the development and commercialization of Crysvita (burosumab).Source
Competitors
Strengths
Company-specific research
Questions worth answering for RARE
These questions are generated from this company's current financial and score data so the page adds context instead of treating the headline score as a stand-alone conclusion.
- •Can RARE maintain its current revenue growth rate and improve the amount of that revenue that turns into earnings and cash?
- •How long can RARE fund negative free cash flow using its current cash position before it may need more debt or new shares?
- •Is RARE's debt load manageable relative to cash generation, interest costs and upcoming maturities?
- •What specifically needs to improve for RARE to reach sustainable profitability?
- •What future growth or profitability would be needed to justify RARE's current valuation?
Essential Investment Snapshot
Market Cap
$1.70B
P/E Ratio
-2.6
EPS
$-5.84
52-Week High
$39.89
52-Week Low
$12.73
Beta
0.32
Analyst Target
$23.00
Shares Outstanding
98.6M
Total Debt
$1.20B
Dividend
No current dividend
Liquidation Value / Share
$-2.88
Momentum & Volatility Signals
Two different market-behavior signals. Momentum measures direction and trend strength. Volatility measures how large and unstable the price moves are, regardless of direction.
Building upward momentum
Normal movement
A high momentum score means price has been trending upward with confirming short- and medium-term strength. A low score means downward or weakening momentum.
A high volatility score means larger, less stable price swings. It can happen while a stock is rising or falling, so high volatility is not automatically bullish or bearish.
Important: the volatility score above is based on realized price volatility. Implied volatility (IV) comes from options prices and represents the market's expected future movement. Wall Street Score will keep IV separate and will only display it when a verified options-chain feed is available.
Notices for RARE
Detected from reported data — verify before acting.Severe debt stress
Negative shareholder equity • Total debt is at least one year of revenue • Interest coverage is below 2x • Free cash flow is negative • Cash covers less than 20% of total debt
M&A headline · Oct 14, 2026
Rep. Gilbert Ray Cisneros, Jr. Acquires Shares of Taiwan Semiconductor Manufacturing Company Ltd. (NYSE:TSM) — This is a provider-linked headline, not an independently confirmed event. Check the article and company filings for the subject, proposed/completed status, and subsequent updates.
Defense WorldCommunity Sentiment
0 active · 0 total callsNo personal call yet on RARE.
Potential upside factors
- +Growth opportunities may come from revenue expansion, margin improvement, new products, market-share gains, and stronger cash flow.
- +Experienced management team in rare disease drug development.
- +Portfolio of approved commercial products for rare genetic diseases.
Potential downside factors
- −Debt risk (severe): Negative shareholder equity.
- −Total debt is at least one year of revenue.
- −Interest coverage is below 2x.
- −Free cash flow is negative.
These research factors come from saved company research and financial data, not community votes. They are starting points to verify against filings, not buy or sell recommendations.
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Scores
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Score Changes
Score changes will appear once more historical records are available.
Price vs. Value
Valuation unavailableCurrent Price
$17.20
Model Intrinsic Value
—
Difference
—
Margin of Safety
—
Intrinsic value is not currently available for this stock, so valuation can't be calculated.
Financial Charts
Revenue
Additional Metrics
Operating Cash Flow
Total Debt
Total Assets
Net Margin %
Free includes 3 annual periods plus available TTM; Premium includes up to 10 annual periods. History depends on available company filings. Swipe the table horizontally to see older periods. A dash means unavailable, not zero.
| Line Item | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $716.9M | $673.0M | $560.2M | $434.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Cost of Revenue | $121.0M | $109.0M | $76.7M | $45.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Gross Profit | $595.9M | $564.0M | $483.5M | $389.0M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Research & Development | $773.2M | $750.0M | $697.9M | $648.4M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| SG&A Expenses | $351.6M | $349.0M | $321.6M | $309.8M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Expenses | $1.12B | $1.10B | $1.02B | $958.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| EBITDA | -$473.0M | -$474.0M | -$469.0M | -$516.5M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Income | -$528.9M | -$535.0M | -$536.0M | -$569.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Interest Expense | $76.1M | $62.0M | $63.0M | $66.0M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Before Tax | -$582.5M | -$571.0M | -$567.6M | -$608.5M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Tax Expense | $3.9M | $4.0M | $1.6M | -$1.8M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Net Income | -$586.4M | -$575.0M | -$569.2M | -$606.6M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic EPS | $-5.84 | $-5.83 | $-6.29 | $-8.25 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic Shares | 102M | 98.60M | 90.54M | 73.54M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Diluted Shares | 102M | 98.60M | 90.54M | 73.54M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
Earnings Summary
Revenue
$214.0M
Estimate unavailable.
Revenue Beat/Miss
Not available (no estimate stored)
EPS
-$0.90
Estimate unavailable.
EPS Beat/Miss
Not available (no estimate stored)
Debt Change
+3211.6%
Cash Change
-24.7%
Margin Change
+26.1 pp
Debt and cash show percentage changes versus the comparison period; margin shows the change in percentage points (pp). These are company-wide changes, not per-share amounts.
Financial Changes Since Prior Period
What Improved
- Margins expanded
What Weakened
- Cash position declined
- Debt increased
Potential Score Impact
Positive indicators included revenue growth, net income margin. Pressure indicators included EPS growth, cash levels, debt levels. These factors may support or pressure the Revenue, Management, Financial, and Debt categories; this summary does not claim that the stored scores changed.
Stored Earnings Analysis
Revenue increased 28.5%. EPS declined 23.1%. Cash declined 24.7%. Total debt increased 3211.6%. Net income margin improved by 26.1 percentage points.
Earnings-Call Transcript
Earnings-call transcript analysis is not currently available.
These results may influence future scores when the next evaluation is completed.
Insider Activity
Guru / Smart Money
Guru Score
Smart Money
Number of Gurus
Total Guru Value
Avg Portfolio Weight
Largest Holder
Largest Holder %
New Positions
Increased Positions
Reduced Positions
Exited Positions
Net Guru Sentiment
Short Interest
Dividend History
Dividend data is not available yet. Missing data does not mean this company pays no dividend.
Conservative Projected Values
3 Years
$———.——
5 Years
$———.——
10 Years
$———.——
Conservative Projection Rate
——%
Conservative Projected Values — price projections derived from actual 10-year adjusted historical returns, conservatively adjusted and capped at 8% annually. These are distinct from the Outperformance Model Score and WallStreetScore.
Conservative Projected Values
Premium unlocks the 3-year, 5-year, and 10-year conservative projected values with full calculation breakdowns based on actual historical returns.
Start 7-Day Free TrialHistorical Outperformance Record
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Start 7-Day Free TrialHistorical Trends
3 historical recordsHistorical Score Chart
3 of 3 records shownWall Street Score
Debt Score
Revenue Score
Asset Score
Capital Score
Management Score
Moat Score
Valuation Score
Buffett Score
Intrinsic Value
Value Reference
Margin of Safety %
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Ultragenyx Enters into Agreement to Sell Rare Pediatric Disease Priority Review Voucher for $203 Million
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Rumor Mill · RARE
Corporate developments & opportunities
No reviewed developments match this filter.
Evidence credibility is not a forecast of stock performance. Rumor Mill is separate from the WSS score.
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