Palisade Bio, Inc.
The research page contains a warning that has not been mapped to a supported model interpretation. The company research remains available, but the complete score is withheld until the warning is reviewed.
PALI · Price history
Price at last available close
$1.19
−$0.26 (-17.93%) 1M
2026-10-28
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Company & revenue
About Palisade Bio, Inc.
Primary reporting period: 2025-12-31 · Research updated Oct 12, 2026. A research update is not a new financial filing.
Who they are
Palisade Bio, Inc., a clinical-stage biopharmaceutical company, engages in developing oral phosphodiesterase-4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon in the United States. Its lead clinical product candidate includes PALI-2108, which is in phase 1b clinical trial to treat patients with inflammatory bowel disease, including ulcerative colitis and Fibrostenotic Crohn’s disease. The company has a research collaboration and license agreement with Giiant Pharma, Inc. for the development, manufacture, and commercialization of its compounds; license agreement with the Regents of the University of California for sole purpose of maintaining the Newsoara Co-Development; and a co-development and distribution agreement with Newsoara Biopharma Co.
How they make money
Palisade Bio is a clinical-stage biopharmaceutical company focused on developing oral therapies for patients with gastrointestinal diseases. The company currently operates as a research and development entity and has not yet generated revenue from product sales, relying instead on capital raises and potential future licensing or collaboration agreements.
Products & services
The company is developing PALI-2108, an oral, prodrug therapeutic candidate designed for the treatment of ulcerative colitis and other inflammatory bowel diseases.
Brands & revenue mix
No separate brand or brand-level revenue disclosure was confirmed in the reviewed sources. This does not mean the company has no brands.
Product / operating segments
No reconciled product or operating-segment revenue breakdown is available for the current research period. Company-wide revenue remains separate from segment disclosure.
Geographic revenue
No reconciled geographic revenue breakdown was confirmed for the current research period.
Customer concentration
No quantified customer-concentration disclosure is available in the current saved research.
Suppliers, materials & equipment
- Contract Research Organizations (CROs) — The company relies on third-party contract research organizations to conduct clinical trials and preclinical studies.Source
- Contract Manufacturing Organizations (CMOs) — The company utilizes third-party contract manufacturing organizations for the production of clinical trial materials.Source
Strengths
- Proprietary prodrug technology platformSource
Sources
Company-specific research
Questions worth answering for PALI
These questions are generated from this company's current financial and score data so the page adds context instead of treating the headline score as a stand-alone conclusion.
- •How long can PALI fund negative free cash flow using its current cash position before it may need more debt or new shares?
- •How is PALI likely to use its cash advantage: reinvestment, acquisitions, debt reduction, dividends or buybacks?
- •What specifically needs to improve for PALI to reach sustainable profitability?
- •What future growth or profitability would be needed to justify PALI's current valuation?
- •What does the current fundamental change risk warning mean for the reliability or interpretation of PALI's score?
Essential Investment Snapshot
Market Cap
$207.4M
P/E Ratio
-3.0
EPS
$-0.53
52-Week High
$2.86
52-Week Low
$1.32
Beta
1.62
Analyst Target
$4.50
Shares Outstanding
173.6M
Total Debt
$71K
Dividend
No current dividend
Liquidation Value / Share
$0.70
Momentum & Volatility Signals
Two different market-behavior signals. Momentum measures direction and trend strength. Volatility measures how large and unstable the price moves are, regardless of direction.
Strong downward momentum
Elevated movement
A high momentum score means price has been trending upward with confirming short- and medium-term strength. A low score means downward or weakening momentum.
A high volatility score means larger, less stable price swings. It can happen while a stock is rising or falling, so high volatility is not automatically bullish or bearish.
Important: the volatility score above is based on realized price volatility. Implied volatility (IV) comes from options prices and represents the market's expected future movement. Wall Street Score will keep IV separate and will only display it when a verified options-chain feed is available.
Notices for PALI
Detected from reported data — verify before acting.Debt service risk
Interest coverage is low (~-1805.6x). Earnings may be strained to cover interest expense.
Community Sentiment
0 active · 0 total callsNo personal call yet on PALI.
Potential upside factors
- +Growth opportunities may come from revenue expansion, margin improvement, new products, market-share gains, and stronger cash flow.
- +Proprietary prodrug technology platform.
Potential downside factors
- −Key risks may include competition, margin pressure, debt levels, valuation risk, and changes in demand within the Biotechnology industry.
- −History of operating losses and expectation of future losses.
- −Dependence on the success of a single clinical-stage product candidate.
- −Requirement for additional capital to fund operations.
These research factors come from saved company research and financial data, not community votes. They are starting points to verify against filings, not buy or sell recommendations.
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Scores
Click any score for full breakdownWas this stock page easy to understand?
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Score Changes
Score changes will appear once more historical records are available.
Price vs. Value
Valuation unavailableCurrent Price
$1.19
Model Intrinsic Value
—
Difference
—
Margin of Safety
—
Intrinsic value is not currently available for this stock, so valuation can't be calculated.
Financial Charts
Revenue
Additional Metrics
Operating Cash Flow
Total Debt
Total Assets
Net Margin %
Large reported revenue change: +1524.0%
Revenue changed sharply from 2019 to 2023. This can reflect a real business change, acquisition, divestiture, discontinued operations, restatement, or reporting-basis change. Compare the underlying filing before treating it as normal growth or decline.
TTM may combine quarters from before and after the event, so its trend can also be distorted.
Free includes 3 annual periods plus available TTM; Premium includes up to 10 annual periods. History depends on available company filings. Swipe the table horizontally to see older periods. A dash means unavailable, not zero.
| Line Item | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | — | $0.00 | $0.00 | $250K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Cost of Revenue | — | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Gross Profit | — | $0.00 | $0.00 | $250K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Research & Development | — | $10.2M | $9.1M | $6.9M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| SG&A Expenses | — | $7.9M | $5.8M | $6.2M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Expenses | — | $18.1M | $14.9M | $13.3M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| EBITDA | — | -$16.8M | -$14.4M | -$12.3M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Operating Income | — | -$18.1M | -$14.9M | -$13.1M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Interest Expense | — | $10K | $12K | $15K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Before Tax | — | -$16.8M | -$14.4M | -$12.3M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Income Tax Expense | — | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Net Income | — | -$16.8M | -$14.4M | -$12.3M | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic EPS | — | $-0.30 | $-10.19 | $-27.01 | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Basic Shares | 211M | 55.67M | 1.42M | 456K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
| Diluted Shares | 211M | 55.67M | 1.42M | 456K | ···· | ···· | ···· | ···· | ···· | ···· | ···· |
Earnings Summary
Revenue
$500000
Estimate unavailable.
Revenue Beat/Miss
Not available (no estimate stored)
EPS
-$0.05
Estimate unavailable.
EPS Beat/Miss
Not available (no estimate stored)
Debt Change
-100.0%
Cash Change
+2210.7%
Margin Change
Not available
Debt and cash show percentage changes versus the comparison period; margin shows the change in percentage points (pp). These are company-wide changes, not per-share amounts.
Financial Changes Since Prior Period
What Improved
- Cash position grew
- Debt reduced
Potential Score Impact
Positive indicators included cash levels, debt levels. Pressure indicators included EPS growth. These factors may support or pressure the Revenue, Management, Financial, and Debt categories; this summary does not claim that the stored scores changed.
Stored Earnings Analysis
EPS declined 91.4%. Cash increased 2210.7%. Total debt declined 100.0%.
Earnings-Call Transcript
Earnings-call transcript analysis is not currently available.
These results may influence future scores when the next evaluation is completed.
Insider Activity
Guru / Smart Money
Guru Score
Smart Money
Number of Gurus
Total Guru Value
Avg Portfolio Weight
Largest Holder
Largest Holder %
New Positions
Increased Positions
Reduced Positions
Exited Positions
Net Guru Sentiment
Short Interest
Dividend History
Dividend data is not available yet. Missing data does not mean this company pays no dividend.
Conservative Projected Values
3 Years
$———.——
5 Years
$———.——
10 Years
$———.——
Conservative Projection Rate
——%
Conservative Projected Values — price projections derived from actual 10-year adjusted historical returns, conservatively adjusted and capped at 8% annually. These are distinct from the Outperformance Model Score and WallStreetScore.
Conservative Projected Values
Premium unlocks the 3-year, 5-year, and 10-year conservative projected values with full calculation breakdowns based on actual historical returns.
Start 7-Day Free TrialHistorical Outperformance Record
Premium includes stored forecasts and any available evaluated results. Completed results, win rates and calibrated probabilities are shown only when supported records exist; access does not create historical outcomes.
Start 7-Day Free TrialHistorical Trends
4 historical recordsHistorical Score Chart
3 of 4 records shownWall Street Score
Debt Score
Revenue Score
Asset Score
Capital Score
Management Score
Moat Score
Valuation Score
Buffett Score
Intrinsic Value
Value Reference
Margin of Safety %
Related Companies
BiotechnologyNews
Palisade Bio Presents Rapid Endoscopic Improvement and New Translational Evidence for PALI-2108 in Inflammatory Bowel Disease at UEG Week 2026
Palisade Bio Presents New Clinical, Pharmacokinetic, Pharmacodynamic and Mechanistic Data Strengthening the Phase 2 Rationale for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at ACG 2026
Palisade Bio, Inc. (NASDAQ:PALI) Stock Has Average Target Price of $9.83 According to Analysts
Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn's Disease at UEG Week 2026
Rumor Mill · PALI
Corporate developments & opportunities
No reviewed developments match this filter.
Evidence credibility is not a forecast of stock performance. Rumor Mill is separate from the WSS score.
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