enGene Holdings Inc.
The research page contains a warning that has not been mapped to a supported model interpretation. The company research remains available, but the complete score is withheld until the warning is reviewed.
ENGN · Price history
Price at last available close
$1.55
−$0.42 (-21.22%) 1M
2026-10-28
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Company & revenue
About enGene Holdings Inc.
Primary reporting period: 2025-10-31 · Research updated Oct 12, 2026. A research update is not a new financial filing.
Who they are
Operating through its subsidiary, enGene, Inc., enGene Holdings Inc. functions as a clinical-stage biotechnology firm. Its core mission involves pioneering genetic pharmaceuticals, achieved by administering therapeutic agents directly to mucosal tissues and other bodily organs. A key asset in its pipeline is EG-70, also known as detalimogene voraplasmid.
How they make money
enGene is a clinical-stage biotechnology company that focuses on the research, discovery, and clinical development of genetic medicines. The company does not currently generate revenue from product sales and relies on capital raises and debt facilities to fund its operations and the development of its proprietary non-viral gene therapy platform.
Products & services
The company's lead product candidate is detalimogene voraplasmid (detalimogene), a non-viral gene therapy designed for the treatment of Non-Muscle Invasive Bladder Cancer (NMIBC) using a proprietary DDX delivery vehicle.
Brands & revenue mix
Lead product candidate for the treatment of NMIBC.
Separate brand revenue is not available in this research.Source
Revenue share is not unit sales or a best-seller ranking. Parent brands and included sub-brands can overlap; do not add overlapping rows.
Product / operating segments
No reconciled product or operating-segment revenue breakdown is available for the current research period. Company-wide revenue remains separate from segment disclosure.
Geographic revenue
No reconciled geographic revenue breakdown was confirmed for the current research period.
Customer types
- Patients with Non-Muscle Invasive Bladder CancerSource
Customer concentration
No quantified customer-concentration disclosure is available in the current saved research.
Suppliers, materials & equipment
- Contract Manufacturing Organizations — The company relies on third-party contract manufacturing organizations for the production of its clinical trial materials and drug product candidates.Source
Competitors
- Pharmaceutical and biotechnology companies — The company competes with various entities developing gene therapies and treatments for bladder cancer, including those utilizing viral and non-viral delivery platforms.Source
Strengths
Sources
Company-specific research
Questions worth answering for ENGN
These questions are generated from this company's current financial and score data so the page adds context instead of treating the headline score as a stand-alone conclusion.
- •How long can ENGN fund negative free cash flow using its current cash position before it may need more debt or new shares?
- •Does ENGN's balance between cash and debt leave enough flexibility if business conditions weaken?
- •What specifically needs to improve for ENGN to reach sustainable profitability?
- •What future growth or profitability would be needed to justify ENGN's current valuation?
- •What does the current fundamental change risk warning mean for the reliability or interpretation of ENGN's score?
Essential Investment Snapshot
Market Cap
$103.9M
P/E Ratio
-7.1
EPS
$-0.28
52-Week High
$12.25
52-Week Low
$1.40
Beta
-0.27
Analyst Target
$3.00
Shares Outstanding
51.1M
Total Debt
$33.3M
Dividend
No current dividend
Liquidation Value / Share
$4.50
Momentum & Volatility Signals
Two different market-behavior signals. Momentum measures direction and trend strength. Volatility measures how large and unstable the price moves are, regardless of direction.
Strong downward momentum
Normal movement
A high momentum score means price has been trending upward with confirming short- and medium-term strength. A low score means downward or weakening momentum.
A high volatility score means larger, less stable price swings. It can happen while a stock is rising or falling, so high volatility is not automatically bullish or bearish.
Important: the volatility score above is based on realized price volatility. Implied volatility (IV) comes from options prices and represents the market's expected future movement. Wall Street Score will keep IV separate and will only display it when a verified options-chain feed is available.
Notices for ENGN
Detected from reported data — verify before acting.Dividend history reported
Dividend payments are recorded. Review the dates and regular/special classification below; past payments do not guarantee future dividends.
Debt service risk
Interest coverage is low (~-41.1x). Earnings may be strained to cover interest expense.
Community Sentiment
0 active · 0 total callsNo personal call yet on ENGN.
Potential upside factors
- +Growth opportunities may come from revenue expansion, margin improvement, new products, market-share gains, and stronger cash flow.
- +Proprietary DDX delivery vehicle technology.
- +Patent-protected manufacturing processes.
Potential downside factors
- −Key risks may include competition, margin pressure, debt levels, valuation risk, and changes in demand within the Biotechnology industry.
- −History of operating losses and expectation of future losses.
- −Dependence on the success of a single lead product candidate.
- −Reliance on third-party manufacturers and suppliers.
These research factors come from saved company research and financial data, not community votes. They are starting points to verify against filings, not buy or sell recommendations.
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Scores
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Score Changes
Score changes will appear once more historical records are available.
Price vs. Value
Valuation unavailableCurrent Price
$1.55
Model Intrinsic Value
—
Difference
—
Margin of Safety
—
Intrinsic value is not currently available for this stock, so valuation can't be calculated.
Financial Charts
Revenue
Additional Metrics
Operating Cash Flow
Total Debt
Total Assets
Net Margin %
Free includes 3 annual periods plus available TTM; Premium includes up to 10 annual periods. History depends on available company filings. Swipe the table horizontally to see older periods. A dash means unavailable, not zero.
| Line Item | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Revenue | $0.00 | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· |
| Cost of Revenue | $547K | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· |
| Gross Profit | -$547K | $0.00 | $0.00 | $0.00 | ···· | ···· | ···· |
| Research & Development | $96.3M | $94.5M | $38.3M | $16.5M | ···· | ···· | ···· |
| SG&A Expenses | $42.7M | $28.7M | $24.0M | $8.5M | ···· | ···· | ···· |
| Operating Expenses | $136.5M | $123.2M | $62.3M | $26.1M | ···· | ···· | ···· |
| EBITDA | -$131.9M | -$113.8M | -$52.0M | -$94.8M | ···· | ···· | ···· |
| Operating Income | -$4.7M | -$123.2M | -$62.3M | -$26.1M | ···· | ···· | ···· |
| Interest Expense | $3.1M | $3.0M | $2.8M | $5.0M | ···· | ···· | ···· |
| Income Before Tax | -$5.4M | -$117.3M | -$55.2M | -$99.9M | ···· | ···· | ···· |
| Income Tax Expense | -$497K | $0.00 | -$19K | $17K | ···· | ···· | ···· |
| Net Income | -$4.9M | -$117.3M | -$55.1M | -$99.9M | ···· | ···· | ···· |
| Basic EPS | $-0.28 | $-2.29 | $-1.46 | $-4.24 | ···· | ···· | ···· |
| Basic Shares | 69.73M | 51.12M | 44.64M | 23.56M | ···· | ···· | ···· |
| Diluted Shares | 69.73M | 51.12M | 44.64M | 23.56M | ···· | ···· | ···· |
Earnings Summary
Revenue
$0
Estimate unavailable.
Revenue Beat/Miss
Not available (no estimate stored)
EPS
$0.47
Estimate unavailable.
EPS Beat/Miss
Not available (no estimate stored)
Debt Change
+6.0%
Cash Change
+25.8%
Margin Change
Not available
Debt and cash show percentage changes versus the comparison period; margin shows the change in percentage points (pp). These are company-wide changes, not per-share amounts.
Financial Changes Since Prior Period
What Improved
- Cash position grew
What Weakened
- Debt increased
Potential Score Impact
Positive indicators included cash levels. Pressure indicators included EPS growth, debt levels. These factors may support or pressure the Revenue, Management, Financial, and Debt categories; this summary does not claim that the stored scores changed.
Stored Earnings Analysis
EPS declined 182.5%. Cash increased 25.8%. Total debt increased 6.0%.
Earnings-Call Transcript
Earnings-call transcript analysis is not currently available.
These results may influence future scores when the next evaluation is completed.
Insider Activity
Guru / Smart Money
Guru Score
Smart Money
Number of Gurus
Total Guru Value
Avg Portfolio Weight
Largest Holder
Largest Holder %
New Positions
Increased Positions
Reduced Positions
Exited Positions
Net Guru Sentiment
Short Interest
Dividend History
Log in to view dividend history.
Conservative Projected Values
3 Years
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5 Years
$———.——
10 Years
$———.——
Conservative Projection Rate
——%
Conservative Projected Values — price projections derived from actual 10-year adjusted historical returns, conservatively adjusted and capped at 8% annually. These are distinct from the Outperformance Model Score and WallStreetScore.
Conservative Projected Values
Premium unlocks the 3-year, 5-year, and 10-year conservative projected values with full calculation breakdowns based on actual historical returns.
Start 7-Day Free TrialHistorical Outperformance Record
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Start 7-Day Free TrialHistorical Trends
6 historical recordsHistorical Score Chart
3 of 6 records shownWall Street Score
Debt Score
Revenue Score
Asset Score
Capital Score
Management Score
Moat Score
Valuation Score
Buffett Score
Intrinsic Value
Value Reference
Margin of Safety %
Related Companies
BiotechnologyNews
enGene Highlights Surfactant-Enhanced Bladder Cancer Therapy Data and 2027 Update Path
enGene Therapeutics Inc. (ENGN) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript
enGene Therapeutics: Slashing Cash Burn To Bring Their Asset To The Market
enGene Reports Third Quarter 2026 Financial Results and Provides Business Update
Rumor Mill · ENGN
Corporate developments & opportunities
No reviewed developments match this filter.
Evidence credibility is not a forecast of stock performance. Rumor Mill is separate from the WSS score.
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