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Primary reporting period: 2025-12-31 · Research updated Oct 12, 2026. A research update is not a new financial filing.
Who they are
Arvinas, Inc. is a biopharmaceutical company in the clinical development stage, dedicated to identifying, advancing, and marketing innovative therapies designed to eliminate disease-causing proteins. The company's pipeline features several promising candidates. These include Bavdegalutamide, a proteolysis targeting chimera (PROTAC) protein degrader, currently in Phase I clinical trials, which specifically targets the androgen receptor (AR) protein to treat metastatic castration-resistant prostate cancer (mCRPC) in men.
How they make money
Arvinas is a clinical-stage biopharmaceutical company that generates revenue primarily through collaboration and licensing agreements with pharmaceutical partners. These arrangements typically involve upfront payments, research funding, and milestone payments contingent upon the successful development and commercialization of its proprietary PROTAC protein degradation therapies.
Products & services
Arvinas develops a new class of drugs based on its proprietary PROTAC Discovery Engine platform, which engineers proteolysis targeting chimeras to degrade disease-causing proteins.
Brands & revenue mix
No separate brand or brand-level revenue disclosure was confirmed in the reviewed sources. This does not mean the company has no brands.
Product / operating segments
No reconciled product or operating-segment revenue breakdown is available for the current research period. Company-wide revenue remains separate from segment disclosure.
Geographic revenue
No reconciled geographic revenue breakdown was confirmed for the current research period.
The company's revenue is highly concentrated in a small number of collaboration partners, with Pfizer and Bayer accounting for a significant portion of total revenue for the fiscal year ended December 31, 2025.
Suppliers, materials & equipment
Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) — The company relies on third-party vendors for clinical trial management, drug substance manufacturing, and drug product formulation; specific supplier names are not disclosed.Source
Business relationships & partnerships
Pfizer Inc. — A strategic collaboration and license agreement for the development and commercialization of ARV-471 (vepdegestrant) for the treatment of patients with ER+/HER2- locally advanced or metastatic breast cancer.Source
Bayer AG — A research collaboration and license agreement focused on the discovery and development of protein degraders for targets in oncology, cardiology, and gynecology.Source
Competitors
Kymera Therapeutics, Inc. — A biotechnology company focused on targeted protein degradation using its proprietary platform.Source
C4 Therapeutics, Inc. — A biopharmaceutical company developing small-molecule medicines that harness the body's natural protein recycling system.Source
Overall investment score · Quality, value, risk and opportunity
38
Poor
PoorElite
View category scores →
Company Quality
How good is the actual business—regardless of today’s stock price?
48
Weak
Financial Strength
39
Business Quality / Moat
66
Management
49
Growth Quality
56
Risk / Durability
19
Weak Company · Expensive Stock
Uses financial strength, moat, management, growth quality and durability. It excludes share price, P/E, market cap, intrinsic value and margin of safety.
Opportunity
Opportunity Score · How does the current price compare with estimated value?
37
Avoid
Based on current valuation, company quality, recent trends, and available market signals.
View score details →
Model Outlook
12-month model · What does the model think happens next?
51/100
Building Historical Record
Model Score 51/100 — estimates relative performance potential, distinct from the overall Wall Street Score and the separate Company Quality score.
Probability unavailable — the model has not produced a calibrated probability yet.
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WSS View
The quick read
The overall Wall Street Score is low across its combined quality, valuation and risk inputs. This can reflect an expensive share price, business weaknesses, or both; check Company Quality and the category breakdown before drawing a conclusion.
At today’s price, the WSS valuation framework currently reads as less attractive based on the available valuation and market data.
The model outlook is currently moderate.
What we like
•Recent buyback activity is present
What to watch
•Valuation is a weaker part of the current profile
•Revenue fundamentals are weak
•Debt / balance-sheet profile needs attention
Company-specific research
Questions worth answering for ARVN
Research inputs 100% complete
These questions are generated from this company's current financial and score data so the page adds context instead of treating the headline score as a stand-alone conclusion.
•Can ARVN maintain its current revenue growth rate and improve the amount of that revenue that turns into earnings and cash?
•How long can ARVN fund negative free cash flow using its current cash position before it may need more debt or new shares?
•How is ARVN likely to use its cash advantage: reinvestment, acquisitions, debt reduction, dividends or buybacks?
•What future growth or profitability would be needed to justify ARVN's current valuation?
Two different market-behavior signals. Momentum measures direction and trend strength. Volatility measures how large and unstable the price moves are, regardless of direction.
A high momentum score means price has been trending upward with confirming short- and medium-term strength. A low score means downward or weakening momentum.
Volatility = How violently is it moving?
A high volatility score means larger, less stable price swings. It can happen while a stock is rising or falling, so high volatility is not automatically bullish or bearish.
Important: the volatility score above is based on realized price volatility. Implied volatility (IV) comes from options prices and represents the market's expected future movement. Wall Street Score will keep IV separate and will only display it when a verified options-chain feed is available.
Notices for ARVN
Detected from reported data — verify before acting.
Historical repurchase activity
Reported cash flows or share-count measures indicate past repurchase activity. This does not verify an active buyback authorization or future purchases.
Community Sentiment
0 active · 0 total calls
0% Bullish (0) 0% Bearish (0)
No personal call yet on ARVN.
Potential upside factors
+Growth opportunities may come from revenue expansion, margin improvement, new products, market-share gains, and stronger cash flow.
+Proprietary PROTAC Discovery Engine platform.
+Strategic collaborations with established pharmaceutical companies.
Potential downside factors
−Key risks may include competition, margin pressure, debt levels, valuation risk, and changes in demand within the Biotechnology industry.
−Dependence on collaboration partners for development and commercialization success.
−History of operating losses and uncertainty of future profitability.
−Negative free cash flow may increase the need for outside financing and dilution.
These research factors come from saved company research and financial data, not community votes. They are starting points to verify against filings, not buy or sell recommendations.
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Scores
Click any score for full breakdown
Wall Street Score
Weak38/ 100
Weak (0–50)Fair (51–71)Strong (72+)
Debt
Fair
50
Debt Cost—
Debt Reduction YoY8.2%
Debt / Equity0.02x
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Revenue
Weak
46
Revenue YoY20.6%
Revenue CAGR82.9%
Net Margin2.9%
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Asset
Fair
52
Asset Growth YoY-34.2%
Liquidation/Share$8.66
Net Assets/MCap1.34x
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Capital
Poor
38
Earnings Yield1.9%
Buyback Yield4.6%
Debt Cost—
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Management
Weak
49
ROIC-24.1%
ROE1.7%
ROA1.4%
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Moat
Fair
66
EPS Growth—
FCF/Share Growth—
Rev/Share Growth27.2%
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Valuation
Poor
4
Intrinsic Value$7.31
Value Reference$4.39
MOS-3.8%
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Buffett
Weak
47
Revenue46
Moat66
Valuation4
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MOS
Poor
0
MOS %-3.8%
Value Reference$4.39
Deep Discount Reference$2.93
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Financial
Poor
39
Interest Coverage—
ROIC-24.1%
FCF Yield-55.2%
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Master
Poor
38
Financial39
Valuation4
Debt50
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Resilience
Fair
60
Survival Years2.5 yrs
Current Ratio4.92x
FCF Margin-105.0%
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Score Changes
6 historical score records available
Previous Score
37
Sep 8, 2026
Change
+0.9
points
Current Score
38
Oct 1, 2026
Category Changes
Revenue+1.3
Debt0
Assets+3.3
Capital+5.0
Management0
Moat0
Valuation0
Buffett+0.7
ARVN increased 0.9 points because Asset improved by 3.3 points, Capital improved by 5 points.
Positive Contributors
+ Asset improved by 3.3 points
+ Capital improved by 5 points
Projected Score
Projected Score
37
Projected Change
-1.2 points
Preliminary comparable-period financial changes suggest decline of approximately 1.2 points. This is a projected estimate, not the official WallStreetScore.
Monetary values in USD. Share counts in raw units.
Income StatementBalance SheetCash Flow
AnnualQuarterlyTTM + Annual
All rows
Free includes 3 annual periods plus available TTM; Premium includes up to 10 annual periods. History depends on available company filings. Swipe the table horizontally to see older periods. A dash means unavailable, not zero.
Line Item
TTM
2025
2024
2023
2022
2021
2020
2019
2018
2017
2016
Revenue
$316.7M
$262.6M
$263.4M
$78.5M
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Cost of Revenue
$11.3M
$5.2M
$0.00
$0.00
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Gross Profit
$305.4M
$257.4M
$263.4M
$78.5M
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Research & Development
$238.4M
$282.9M
$348.2M
$379.7M
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SG&A Expenses
$85.2M
$89.4M
$165.4M
$100.3M
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Operating Expenses
$319.5M
$372.3M
$513.6M
$480.0M
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EBITDA
$2.9M
-$75.3M
-$191.7M
-$359.7M
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Operating Income
-$14.1M
-$114.9M
-$250.2M
-$401.5M
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Interest Expense
$0.00
$0.00
$0.00
$0.00
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Income Before Tax
$10.1M
-$80.5M
-$198.3M
-$366.4M
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Income Tax Expense
$800K
$300K
$600K
$900K
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Net Income
$9.3M
-$80.8M
-$198.9M
-$367.3M
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Basic EPS
$0.19
$-1.28
$-2.77
$-6.62
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Basic Shares
64.80M
64.90M
71.90M
55.50M
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Diluted Shares
65.70M
64.90M
71.90M
55.50M
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Upgrade to Premium for up to 10 annual periods, where available.
Debt and cash show percentage changes versus the comparison period; margin shows the change in percentage points (pp). These are company-wide changes, not per-share amounts.
Financial Changes Since Prior Period
What Improved
Margins expanded
Debt reduced
What Weakened
Cash position declined
Potential Score Impact
Positive indicators included revenue growth, debt levels, net income margin. Pressure indicators included EPS growth, cash levels. These factors may support or pressure the Revenue, Management, Financial, and Debt categories; this summary does not claim that the stored scores changed.
Stored Earnings Analysis
Revenue increased 1014.7%. EPS declined 407.1%. Cash declined 17.9%. Total debt declined 17.2%. Net income margin improved by 341.1 percentage points.
Earnings-Call Transcript
Earnings-call transcript analysis is not currently available.
These results may influence future scores when the next evaluation is completed.
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Government disclosed trading activity is available on the Smart Money directory. Filings may be delayed and may not represent complete current holdings.
Dividend HistoryShare
Dividend History
Dividend data is not available yet. Missing data does not mean this company pays no dividend.
Predictions & Historical PerformanceShare
Conservative Projected Values
3 Years
$———.——
Premium
5 Years
$———.——
Premium
10 Years
$———.——
Premium
Conservative Projection Rate
——%
Premium
Conservative Projected Values — price projections derived from actual 10-year adjusted historical returns, conservatively adjusted and capped at 8% annually. These are distinct from the Outperformance Model Score and WallStreetScore.
Conservative Projected Values
Premium unlocks the 3-year, 5-year, and 10-year conservative projected values with full calculation breakdowns based on actual historical returns.
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